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Nevertheless, in HFD-fed mice showed the obvious rise of liver weight, as well as the elevated hepatic lipid droplets, the accumulated TG, the deposited total cholesterol (TC) [17], which may be related to impaired mitochondrial function due to exogenous intake of excess lipids

VPA induced hepatotoxicity is a welldocumented undesirable effect and can present clinically in different forms such as an asymptomatic and reversible elevation of aminotransferases (alanine transaminase or aspartate aminotransferase), hyperammonaemia with minimal or no liver injury and acute hepatocellular injury with jaundice which can progress to fulminant liver failure

2021;13 doi: 10.3390/nu13072421

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XinL and FY searched the literature