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In 35% of cases, single-gene mutations are responsible, while others correlate with genetic risk variants, family history, constipation, nonsmoking status, and exposure to environmental toxins (e.g., pesticides and trichloroethylene) (149)

Several attempted divisions can occur before sufficient genetic damage is accumulated to trigger mitotic death, underlining why solid tumours often demonstrate delayed responses to RT

Dull skin 3

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