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Still produces systemic effects

All of the substrate cobalt-corrin molecules from which B12 is made must be synthesized by bacteria

Your mileage may vary, but from what Ive seen, most people report the same timeline

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The study population was followed up for a duration of 36 weeks with a primary outcome of development of CIPN with a secondary outcome in this study being the Brief Pain Inventory score

While Semaglutide (Ozempic, Wegovy) targets one receptor and Tirzepatide (Mounjaro, Zepbound) targets two, Retatrutide activates three distinct metabolic receptors simultaneously