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4) Impaired Kidney Function Chronic kidney disease patients had higher TMAO levels compared to controls in a study with 521 patients and 3,166 controls

All the patients fully retained the pigment in the treated areas, which accounted for about 30% of the affected skin, 6 months after completion of the course of mesotherapy

Inzucchi SE, Docherty KF, Kober L, et al

This relative deficiency contributes to mitochondrial dysfunction, impaired substrate metabolism, and metabolic inflexibilitythe inability to efficiently switch between carbohydrate and fat oxidation based on substrate availability

10.1016/j.bbalip.2014.03.013 Biochim Biophys Acta

2012;25(Suppl 1):S1727