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Numerous studies show a positive correlation between the level of TMAO concentration and the onset of several illnesses, including diabetes mellitus, hypertension, ischemic stroke, atrial fibrillation (AF), heart failure (HF), acute myocardial infarction (MI), and chronic kidney disease (CKD) [5]

[DOI] [PubMed] [Google Scholar] 106.Reddy BS, Narisawa T, Weisburger JH

Consistency, hydration, and proper nutrition are equally important

#4: Valproic acid or phenobarbital (whichever you didnt choose as #3)

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6.2 Insufficient depth and integration of mechanistic studies Although existing studies have identified the involvement of multiple signaling pathwayssuch as AMPK, PPAR, SREBP, and FXRin hawthorn-mediated regulation of lipid metabolic homeostasis, most investigations remain confined to single-pathway validation and lack systematic analysis of the interactions among these pathways