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Think of it like a wave: high amplitude means a big swing between wide awake during the day and deeply asleep at night

Vitamin B12 is water-soluble, meaning your body will typically eliminate any excess through urine

Houston and Walkinshaw, 2013

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Fischer, P

Specifically, intra-articular injection or systemic administration of specific ferroptosis inhibitors such as ferrostatin-1, or pharmacologically for example, using natural products or genetically for example, using overexpression vectors upregulating GPX4 expression, activating SLC7A11, or the key transcription factor Nrf2, can, to varying degrees, restore cartilage morphology, reduce chondrocyte death, and significantly lower the expression levels of ECM degradation markers in OA animal models