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Intriguingly, RNA-seq analysis from very rare brain material obtained from two patients with HD at the asymptomatic phase showed similar alterations in striatal GSTO2
Feng H, Schorpp K, Jin J, et al

In a study, apelin-13the most biologically active form of apelinexerted protective effects against oxidative stress induced by renal I/R injury

10.1161/CIRCULATIONAHA.111.060368 152 Sharifi-RadMKumarN

Inactivation of the HIF-1/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants

In addition, there are potential risks of brain tissue damage and significant fluctuations in intracranial pressure
