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Cocaine causes alterations in the gut microbiota of mice and is associated with the upregulation of pro-inflammatory mediators, such as nuclear factor-kappa B and IL-1 (202)

Overall prevalence is 1 in 30,000, and around 1 in 90 people are carriers of the defective gene[2,4]

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While DA toxicity did not induce apparent cytoprotective responses, treatment with undiluted (i.e., 100% v/v) methyl-salicylate (MS), an odorant chemically closely related to BA stimulated identical molecular defenses, including DAF-16 translocation as well as activation of the gst-4 and cyp-35B promoters 26

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