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Additionally, mRNA expression of iron response element binding protein 2, encodes a master regulator of iron metabolism), and CS (citrate synthase, regulating the mitochondrial fatty acid metabolism) was upregulated in both models, while ACSF2 ((acyl-CoA synthetase family member 2, regulating the mitochondrial fatty acid metabolism) was upregulated only in APPswe/PS1dE9 mice

Weyand, Targets of immune regeneration in rheumatoid arthritis, Mayo Clinic Proceedings, vol

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Acuna Castroviejo, D., Rosenstein, R

The respiratory region, which forms the largest part of the nasal cavity, is highly vascularised, allowing drugs deposited there to be rapidly absorbed into the systemic circulation and potentially reach the brain after crossing the BBB (Jeong et al., 2023)