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When levels dip, the effects can be quite noticeable, even debilitating

The expression of CD38 is not limited to immune cell types, such as NK cells, T cells, B cells, monocytes, Treg cells, and Breg cells, it is also widely expressed in non-hematopoietic tissues such as the heart, brain, pancreas, and lungs

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But for others, the gut doesnt absorb B12 efficiently due to health conditions, medications, or age-related changes in the stomach lining

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doi: 10.1113/jphysiol.1985.sp015602