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Any discomfort is minimal and temporary

Zhang et al., 2009)

(2000) Genomic expression programs in the response of yeast cells to environmental changes

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Moreover, despite recent findings of a guanine nucleotide exchange factor (GEF) and GAPs for the Rag GTPases and the requirement of vacuolar H + -ATPase (v-ATPase, a proton pump for lysosomal acidification) in mTORC1 activation (4145), the signaling mechanism from amino acids to a Rag GEF and/or GAP is still unknown

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