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Scientific and clinical monograph for Pycnogenol

Physiological Roles of Cellular and Tissue Stress Even under physiological conditions, cells rarely exist in perfectly optimal microenvironments, and low-intensity damaging inputs (including stochastic mutational events) are unavoidable

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Estrela, PedroAnalytical Chemistry (Washington, DC, United States) (2016), 88 (23), 11486-11490CODEN: ANCHAM

excessive NO production leading to ONOO , which in turn can cause protein nitration)

This oxidative damage-induced cell death affects hepatocytes and involves LSECs and cholangiocytes