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With a B12 deficiency, the body may produce fragile red blood cells that break down more easily, releasing a yellow pigment called bilirubin

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doi: 10.1186/s12967-020-02374-0 10 MeizlishMLPineABBishaiJDGoshuaGNadelmannERSimonovMet al

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Such phosphorylation leads to the blockade of the tyrosine residues in IRSs, to which the insulin and IGF-1 receptors phosphorylate to activate IRSs and consequently commence the signalling cascade [185, 192], as comprehensively discussed above

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