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Injections are better suited to people with absorption disorders, such as Crohn's disease or pernicious anemia, because the dose enters the bloodstream directly

Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)

Ju, T., Kong, J

doi: 10.1056/NEJMoa1908681 49

Some sources suggest the compound is well-absorbed orally based on rat pharmacokinetic data, while others argue that subcutaneous injection provides more reliable absorption

It is thought that hormonal changes such as this hypocortisolism may result in symptoms of fatigue experienced by patients (255, 428, 429)