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Description
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This mutation reduces, but does not abolish carnitine transport and affects glycosylation and maturation to the plasma membrane of the OCTN2 carnitine transporter [146]
Mechanistically, PA disrupts intracellular iron homeostasis via ER calcium release, upregulates transferrin (TF)-mediated iron transport, and ultimately triggers ferroptotic death through iron overload ( 2.4 Induction of cell cycle arrest Cell cycle arrest, achieved by downregulating cyclins and cyclin-dependent kinases (CDKs), represents a key anti-cancer strategy
[DOI] [Google Scholar] 117.Elder J.H., Shankar M., Shuster J., Theriaque D., Burns S., Sherrill L
