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Bevacizumab, a monoclonal antibody targeting VEGF, is categorised as FDA Pregnancy Category C (risk cannot be ruled out) based on animal studies showing embryo-foetal toxicity

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doi:10.1124/jpet.108.141333

Most studies investigated circuit and subpopulation effects of opioid receptors in pallidum have focused on VP, therefore future studies are needed to identify specific subpopulation effects in GP and EPN