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Peptides affecting similar pathways may produce diminishing returns rather than synergy

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In some embodiments, the percentage of active pharmaceutical ingredient is varied between about 0.01% and about 20%, between about 0.01% and about 10%, between about 0.01% and about 5% or more of the weight or volume of the total pharmaceutical formulation or composition

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23,124 Recently, the trans-tight junction patch clamp approach has been developed to elucidate the gating characteristics of an independent, single claudin-2 channel in Tet-off regulated claudin-2-inducible MDCKI monolayers, which revealed the claudin-2-dependent conductance of ~9 pA

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