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The copper peptide evidence includes a 2012 review by Pickart et al

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He Z, Zhao Y, Rau MJ, Fitzpatrick JAJ, Sah R, Hu H, et al

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However, clinical outcomes have been inconsistent, ranging from apparent benefit to complete lack of efficacy

Since cognitive behavioral therapy for insomnia (CBTi) can enhance sleep quality and support endogenous antioxidant defenses, combining natural sleep interventions with pharmacological NRF2 activators such as dimethyl fumarate and sulforaphane may reinforce these pathways, stabilizing sleep patterns, reducing pain hypersensitivity, and improving fatigue