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A comprehensive systematic review and meta-analysis published in the Journal of Translational Medicine analyzed data from seven distinct studies encompassing over 400 patients

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[143] FosB is the most significant biomolecular mechanism in addiction because FosB overexpression (i.e., an abnormally high level of gene expression which produces a pronounced gene-related phenotype) in the D1-type medium spiny neurons in the nucleus accumbens is necessary and sufficient [note 13] for many of the neural adaptations and regulates multiple behavioral effects (e.g., reward sensitization and escalating drug self-administration) involved in addiction

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Excitotoxicity Glutamate (Glu), which is the main excitatory neurotransmitter in the brain, has been reported to have an important role in METH-induced excitotoxicity (Moratalla et al., 2017)

Yerba mate and acai berry possess useful pharmacological such as anti-inflammatory, anti-diabetic, antioxidant, in vitro anticancer, inhibition of topoisomerase II, anti-obesity and reduces LDL cholesterol levels