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Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion

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This -glutamyl peptide linkage resists splitting by most peptidases

10.1161/01.ATV.0000168414.06853.F0 59 KimK

These polymorphisms are likely to contribute to the difference between individuals in responses to xenobiotics and clearance of oxidative stress products and have been associated with various pathologies such as cancer, and cardiovascular or respiratory diseases [60]