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instead, it is intricately woven into the fabric of specific proteins to create selenoproteins

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Abbreviations ROS: Reactive oxygen species PUFAs: Polyunsaturated fatty acids NOXs: NADPH oxidases XO: Xanthine oxidase mETC: Mitochondrial electron-transport chain SOD: Superoxide dismutase CAT: Catalase HNE: Hydroxynonenal PL: Phospholipid LOX: Lipoxygenase Alox: Arachidonate lipoxygenase PLA2: Phospholipase A2 GPx: Glutathione peroxidase Trx: Thioredoxin TrxR: Thioredoxin reductase GSH: Glutathione GSSG: Glutathione disulfide CoQ10: Coenzyme Q10 HIF-1 : Hypoxia inducible factor-1 MAPKs: Mitogen-activated protein kinases ERK: Extracellular signal-regulated kinase JNK: Jun N-terminal kinase PKC: Protein kinase C CMA: Chaperone-mediated autophagy LC3: Light chain 3 mTOR: Mammalian target of rapamycin AMPK: Adenosine monophosphate-activated protein kinase TSC: Tuberous sclerosis complex LIP: Labile iron pool DFO: Deferoxamine CPX: Ciclopirox

MUNC13-4 restricts motility of RAB27A-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils