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For individuals with specific genetic polymorphisms or with likely interactions with the nutrients or medicines that may impair folate metabolism, personalized interventions or targeted supplementation strategies may be required to optimize folate bioavailability

Acosta, L., Byham-Gray, L., Kurzer, M

10.1016/s0928-4257(99)00120-5 87 PetrovicI.DobricI.DrvisP.ShejbalD.BrcicL.BlagaicA

This allows for precise drawing of the microgram doses recommended for administration

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Beyond mediating intersystem communication between the immune and nervous systems, growing evidence suggests that GABA can also act as a paracrine signalling molecule mediating intrasystem communication to regulate immune response 33