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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Zinc Deficiency, Excess and Supplementation

As Lissoni et al works reported, Melatonin is useful in chemotherapy of cancer patient with poor clinical condition [96], advanced cancer patient with normal clinical status [96] and improve the efficacy of anthracyclines, cisplatin, 5fluorourcil, etoposide, gemcitabine, taxanes, raltitrexedand, isofosfamide [96,97].] Melatonin through numerous biological mechanisms is able to influence hosttumor interactions which may change both tumor and host characteristics [98- 100]

mTOR-mediated regulation of dendritic cell differentiation and function

Furthermore, breakdowns within the cycle can also lead to decreased levels of CoQ10, a critical component of energy production on the cellular level