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Postmortem studies demonstrate that in active lesions of the white matter and cerebral cortex, demyelination and neurodegeneration are closely associated with the presence of oxidized lipids (such as oxidized phospholipids and MDA) in myelin membranes and in apoptotic oligodendrocytes and neurons, in which oxidized DNA can be found within their nuclei [68,69,70]

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Garg R, Garcia-Manero G, Faderl S, Cortes J, Koller C, Beran M, Borthakur G , Kantarjian H, Ravandi F

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Preston G, Emmerzaal T, Kirdar F, Schrader L, Henckens M, Morava E, Kozicz T (2020) Cerebellar mitochondrial dysfunction and concomitant multi-system fatty acid oxidation defects are sufficient to discriminate PTSD-like and resilient male mice