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The increased sensitivity of these two ASK1-dependent pathways in Nrf2-null fibroblasts is consistent with the mutant cells possessing heightened activity of ROS-sensitive signal transduction pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Candas D., Li J.J

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This would lead to the accumulation of senescent cells, the persistence of their pro-inflammatory SASP, and the chronic inflammation and tissue disruption seen in the disease, further reinforcing the pathological cycle

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Oxidative/nitrative modifications of plasma proteins and thiols from patients with schizophrenia