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By binding to copper at the active site of tyrosinase and interfering with melanin synthesis intermediates, glutathione reduces overall melanin formation. As a powerful antioxidant, glutathione also reduces free radicalinduced oxidative stress, which is one of the triggers for increased tyrosinase activity and melanin production

186 This suggests that targeting USP20 may mitigate chemotherapy resistance and promote ferroptosis in HCC patients, and explains why DNA damage therapy often leads to treatment resistance

Bleich M

TSH-TSHR axis promotes tumor immune evasion

thus, what regulates axon regeneration remains a field of interest to scientists

doi: 10.1016/j.injury.2017.07.005