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however, little is known about how oxidative stress may play a critical role in this condition (Hulsebosch et al., Evidence supports that after a central nervous system injury, increased extracellular glutamate levels activate several intracellular pathways including ROS formation

Increased liver lipid accumulation and decreased liver and serum folate levels were also found in a high-fat diet (HFD)-induced obesity mouse model ( Reduced serum folate levels have been observed in patients with MASLD and animal models, indicating a possible relationship between disruptions in folate status and the progression of MASLD

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Liu Q, Huang J, Yan W, Liu Z, Liu S, Fang W

Cytoprotection by HO-1 against OS results from the generation of three products: carbon monoxide (CO), biliverdin-bilirubin, and ferrous iron (Fe +2 )