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The 2021 Akar paper in Journal of Obstetrics and Gynaecology documented anti-proliferative activity of small-molecule NNMT inhibitors in HeLa cell systems (PMID 33645410)

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It can be detected in both plasma and urine using specialized LC/MS/MS assay methods for several days post-administration

(5) Research has shown that by preserving nicotinamide from NNMT-mediated degradation, the compound may enhance NAD+ synthesis through the salvage pathway
