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The therapeutic activation of this pathway with compounds such as dimethyl fumarate, tert-butylhydroquinone and sulforaphane can inhibit ferroptosis by upregulating the expression of downstream antioxidant genes (57)
A critical barrier to improving patient outcomes is the frequent absence of discernible symptoms during early disease progression, leading to delayed diagnosis and unfavourable prognoses
F., and Hirayama B
PMCID: PMC7019700
In athletic populations, NAC supplementation has been linked to improved oxidative stress markers, suggesting that it may support recovery and reduce fatigue
Other benefits include lowering inflammation, and nutrient partitioning
