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A recent study found that people taking the antidiabetes drugs semaglutide or tirzepatide were 37% less likely to develop dementia than those taking other diabetes medications

Given that LCL-161 is currently undergoing phase 2 clinical trials for MM, these findings suggest that SMs may offer additional clinical benefits by mitigating bone degradation in myeloma patients (8)

The signaling cascade of caspases responsible for inducing mitochondrial apoptosis is activated by ROS

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These molecular alterations collectively reduce the activation threshold and expand the receptive fields of secondorder widedynamicrange neurons, enabling normally subthreshold inputs from lowthreshold A mechanoreceptors to gain access to and activate nociceptive circuits

10.1093/gerona/glae252 12 AltmanN