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The basic strategy is to obtain a reagent focusing its activity prevalently around the cells expressing CD38, which enables avidity-induced blocking of CD47 on the same cells, in this way avoiding unwanted off-tumor effects

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Compare that to the 60/40 split some semaglutide studies show, and the difference over a 50-pound weight loss would be an additional 2-7 pounds of preserved lean mass

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Without a firm grasp of this single data point, designing a successful research protocol is like trying to navigate a ship in a storm without a compass

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