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Glycogen synthase kinase-3 haploinsufficiency mimics the behavioral and molecular effects of lithium

At regular intervals 0, 30 and 90 days, a sample was taken for analysis

We found that 2-HG levels accumulated across the continual stimulation time course, but were only slightly increased upon acute stimulation, peaking at 12 h (Figs

[PubMed Central ID: PMC7699613]

However, only the animals that were administered with the incretin-based compounds (GLP-1 and GLP-1MK-801) displayed increased baseline-corrected glucose-stimulated insulin secretion (Extended Data Fig

Movie frames were aligned using patch motion in CryoSPARC 3.1 (54)