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Further comparative biochemical and pharmacological investigations are necessary before asserting that DHK-Cu merits the same recognition as its more established equivalents [2]

An umbrella meta-analysis published in Clinical Therapeutics in 2023, which analyzed 11 prior meta-analyses of randomized controlled trials, confirmed that berberine supplementation was effective in reducing fasting blood glucose, HbA1c, HOMA-IR (a marker of insulin resistance), fasting insulin levels, and inflammatory biomarkers including CRP, TNF-alpha, and IL-6

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These three types comprise almost all of the collagen in our bodies, making them the most common variants in dietary supplements