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Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits

Therefore, although GSH treatment exerted a significant protective effect against OXA-induced liver injury in the present study, hepatic oxidative stress continues to occur

For immunofluorescence, the second-to-last wash included 1 g ml 1 4,6-diamidino-2-phenylindole dihydrochloride (DAPI

However, in a clinical intervention of short-term NAC administration in NPC1 patients (NCT00975689), the plasma levels of 7-ketocholesterol, 3,5,6-cholestanetriol, and GSH/GSSG ratio did not change significantly, suggesting a limited efficacy of NAC in the advanced stage of the disease [130]

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