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FBS, fetal bovine serum

An increased kynurenine/tryptophan (Kyn/Trp) ratio correlates with disease The kynurenine pathway is a major route of tryptophan metabolism in humans, in which the enzyme indoleamine 2,3-dioxygenase ( IDO1 ) converts tryptophan to kynurenine via the intermediate N-formyl L-kynurenine, followed by deformylation mediated by arylformamidase [58,59,60], for a schematic illustration, see Fig

Thymectomy The thymus gland, a component of the immune system located under the breast bone, is responsible for the production and maturation of certain immune cells

Blood glucose and fasting insulin levels were markedly elevated in HFD-fed mice and showed a higher HOMA insulin resistance index (Fig
