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The synthetic analogue of -MSH, Afamelanotide (also called Melanotan I), in association with phototherapy, demonstrated some positive effects due to its capacity to promote melanocyte proliferation and pigment production [94]

In older lesions the predominant color is dark red, probably due to the presence of crusts and vascular disarrangement, with irregular vessels assuming a mix of hairpin, linear, or dotty aspect

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Regulation of cholesterol 7-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXR)