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88 Moreover, the probiotic Lactobacillus acidophilus can maintain the homeostasis of inflammatory factors and improve intestinal barrier dysfunction in vitro and in vivo by promoting autophagy

Downregulated in HCC 31,32,33 , HNF4 is considered as a tumor suppressor that represses the development of HCC and inhibit epithelial-mesenchymal transition (EMT), a process that promotes cancer progression and metastasis 34,35,36