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Description
The goal of the 3R Principle is to avoid animal experiments altogether (Replacement) and to limit the number of animals (Reduction) and their suffering (Refinement) in tests to an absolute minimum
Lactylation, is an emerging post-translational modification that adds lactyl groups to both histone and non-histone proteins, participating in a variety of pathophysiological processes
As the cells energy producers, mitochondria create ATP through a process called oxidative phosphorylation, which uses the electron transport chain (ETC) (41, 89)
The resulting extract was divided into five fractions: two for analysis by two separate reverse phase (RP)/UPLC-MS/MS methods with positive ion mode electrospray ionization (ESI), one for analysis by RP/UPLC-MS/MS with negative ion mode ESI, one for analysis by HILIC/UPLC-MS/MS with negative ion mode ESI, and one sample was reserved for backup
Physiol 236(7):4888901 [DOI] [PMC free article] [PubMed] [Google Scholar] 129.Swenson SA, Moore CM, Marcero JR, Medlock AE, Reddi AR, Khalimonchuk O
Free Radic Res 56(78):572576
