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Cancer cells produce more spatially concentrated ROS than normal cells, which hyperactivates the cell signaling pathways required for cellular transformation and carcinogenesis (Figure 2)

142,143 Conversely, cytoplasmic p53 acts as a negative regulator of autophagy through nontranscriptional mechanisms

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Importantly, the study only explored quetiapine's use in bipolar depression and did not extend its findings to other mental health conditions (Hu et al., 2019)

When a stimulant becomes controversial or prohibited, manufacturers often turn to structurally similar compounds that produce comparable physiological effects but are not yet widely recognized