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Moisturizers The American Academy of Dermatology has called the use of unmedicated topical moisturizers an internationally accepted standard adjunctive therapeutic approach to the treatment of psoriasis . In fact, in controlled trials of corticosteroid topical treatments, in which placebo is essentially an unmedicated moisturizer, placebo response rates of up to 47% have been found, suggesting moisturizers alone have a beneficial effect in psoriasis (Menter 2009)