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In U20 APO/GSH/GS-PAP , this tryptophan residue is buried (accessible surface area (ASA) of 4 2 ), making the H-site quite deep (Supplementary Figure S6)

Crystal structures of human CBS 8,9,10 have been determined of CD alone (CBS CD ), of full-length protein engineered with the RD loop deletion (CBS 516525 ) 16,17,18 , and of RD alone with the loop deletion (CBS RD516525 ) complexed with SAM 17

10.1038/s41598-024-56169-0 133 SchallmoserK.HenschlerR.GabrielC.KohM
doi: 10.1074/jbc.M113.524587

Variability in cultivation conditions, extraction methods, and dosage protocols across studies also complicates direct comparison of results and standardization of health claims

doi: 10.1016/j.blre.2017.06.002 80 BatoolTMakkyEAJalalMYusoffMM
