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GLP-1 agonists cause gastrointestinal side effects including diarrhoea and vomiting in 3045% of patients during dose titration, leading to electrolyte depletion

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Results have also revealed that chondrocytes from Hfe-KO mice were more likely to develop OA-related phenotypic characteristics, such as upregulation of MMPs expression, decreased production of extracellular matrix, and decreased expression of aggrecan

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