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Conclusions The publication of the 2024 NICE guidelines on B 12 deficiency represents progress but falls short by proposing to rename pernicious anaemia with autoimmune gastritis. This change does not adequately address the distinct nature of PA as an advanced stage of AIG, characterised by IF deficiency requiring lifelong B 12 treatment

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It reports purity by HPLC (should be 98% or higher), mass spectrometry confirmation of molecular identity, and endotoxin/sterility testing