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Description
Most people report appetite suppression returning by week 2-3 on tirzepatide, even at the 2.5 mg dose, because the GIP receptor activation adds effects that semaglutide alone could not provide
HbA1c: Hemoglobin A1c

Hypertension 50, 862868
Peptide YY does not inhibit glucose-stimulated insulin secretion in humans
The concern with these medications is that the delayed gastric emptying leads to residual gastric contents, which may increase the risk of aspiration

These necessitate careful patient selection, comprehensive monitoring, and risk mitigation strategies [4,201,202]