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Full Staggered Titration Schedule Recommended staggered co-titration across 24 weeks Phase Reta initiation Weeks 1-4 Retatrutide 2 mg/week Cagrilintide Not started Notes Confirm retatrutide GI tolerance first

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Adv Exp Med Biol (2007) 612:88103.10.1007/978-0-387-74672-2_7 27 SamuelCSCoghlanJPBatemanJF

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The mechanisms of FA-induced insulin resistance have been intensively studied and have been attributed to two metabolites of FAs - DAGs and ceramides