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Shubin AV, Demidyuk IV, Komissarov AA, Rafieva LM, Kostrov SV

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In contrast, the cell growth was significantly inhibited with the combination of BMS-754807 and U0126 comparing with vehicle control, BMS-754807, or U0126 alone

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doi: 10.1038/nrendo.2018.22

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391 While its precise mechanismincluding potential NOX subunit (e.g., p67phox, p47phox) involvementrequires further elucidation, ZIO-101s dual action of ROS induction and mitochondrial impairment effectively promotes cancer cell death

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