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The likely-resulting endotoxemia from intestinal barrier dysfunction stimulates toll-like receptor 4 (TLR4) in Kupffer cells to produce NADPH-oxidase (NOX)-dependent ROS [213] and activate HSCs, leading to fibrosis [144, 219]

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Animals are tested in glass cylinder, where they adapt for 10 minutes prior to assessment

doi: 10.3389/fonc.2022.923043 78 TacchiniLBianchiLBernelli-ZazzeraACairoG

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Vitamin C intake and breast cancer mortality in a cohort of Swedish women