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In autophagy-deficient cells lacking Atg7 or Atg5 , Nrf2 is constitutively activated as a result of p62 accumulation, leading to the induction of cytoprotective genes such as NQO1, HO-1 , and enzymes involved in glutathione metabolism

Studies reveal that obesity-driven matrix deposition creates fibrotic microenvironments that sustain inflammatory responses and compromise insulin signaling pathways (83)

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Ind Crops Prod 140:111597 Khan S, Alvi AF, Saify S, Iqbal N, Khan NA (2024b) The ethylene biosynthetic enzymes, 1-aminocyclopropane-1-carboxylate (ACC) synthase (ACS) and ACC oxidase (ACO): the less-explored players in abiotic stress tolerance

NAD+ is a key co-substrate for enzymes called sirtuins, often referred to as longevity genes or guardians of the genome. Sirtuins regulate cellular health, influence gene expression, and are involved in DNA repair pathways

Diallyl trisulfide protects rat brain tissue against the damage induced by ischemia-reperfusion through the Nrf2 pathway