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doi: 10.1097/01.hjh.0000160199.51158.cf 196

However, the effects of larger doses are not known

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Despite only modest reductions in bulk mTORC1 signaling, the robust induction of this pathway suggests a highly sensitive, localized regulatory circuit where the PIKfyve complex acts as a constitutive brake on cellular repair and metabolic adaptation.The article was published in Nat Commun #genetics #genomics #precisionmedicine #genomicmedicine #brain #neurology #neuroscience #neurodegeneration #membranecontactsites #neuroinflammation #inflammation #immunity #metabolism #lysosome #mitochondria #lipids #autophagy #raredisease #niemannpick #aging #longevity #cognition #dementia #alzheimer #parkinson #geroscience #biomarkers #therapeutics #biotechnology #innovation #research #science #sciencecommunication Instituto To view or add a comment, sign in Creativity is as important as knowledge / Director, Ph.D

Because citrulline is not metabolised by arginase in the liver and is efficiently converted to arginine in the kidneys, it may raise plasma arginine levels more effectively than arginine supplementation itself

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