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Figure 16.27 Distribution Curve Showing the Fraction of Acetic Acid Molecules and Acetate Ions as a Function of pH in a Solution of Acetic Acid The pH range over which the acetic acid/sodium acetate system is an effective buffer (the darker shaded region) corresponds to the region in which appreciable concentrations of both species are present (pH 3.765.76, corresponding to pH = p K a 1)

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Patients with gastrointestinal conditions, absorption disorders, or post-bariatric surgery may not be ideal candidates for oral formulations

Expectations should remain moderate for labral tears

The oral versus injection comparison covers efficacy differences between delivery methods